There is an increasing interest in the treatment of peritoneal cancer with aerosolized chemotherapy, which is instilled in the abdominal cavity during laparoscopy (PIPAC procedure, pressurized intraperitoneal aerosol chemotherapy). The behavior of the aerosol droplets and the anticancer efficacy of the nebulized chemotherapy may be affected by the physiological environment in the peritoneal cavity: temperature, humidity, and pH. In addition, they may affect the efficacy of electrostatic precipitation, which is combined with PIPAC in selected patients. Unfortunately, these parameters have never been investigated in a clinical setting.