32238 Development of a Method to Aerosolize Viscous Drug Carriers in the Peritoneal Cavity of Mice
Begeleider(s): Mohammad Rahimi Gorji

Richtingen: Master of Science in Biomedical Engineering

Probleemstelling:

There is an increasing interest in the treatment of peritoneal cancer with aerosolized chemotherapy, which is instilled in the abdominal cavity during laparoscopy (PIPAC procedure, pressurized intraperitoneal aerosol chemotherapy), often combined with electrostatic precipitation of the aerosol. Further development of the method requires availability of small animal models. While a rat model was recently established, a mouse model is required for anticancer studies. However, due to the small maximal volume of the murine peritoneal cavity (~1 mL), delivery of aerosols in the peritoneal cavity of mice is challenging.


Doelstelling:

The aim of this project is to develop a method that allows intraperitoneal aerosolized delivery in the mouse. The focus will be on viscous agents, since there is a recent interest in gel based prolonged drug delivery systems. Ideally, the proposed solution would be based on a dual (twin) fluid design, where the energy of CO2 gas is used to break up the gel or liquid into droplets.